Bacteria Don’t Have to Be Single Cells: Candidatus Magnetoglobus multicellularis

Bacteria Don’t Have to Be Single Cells: Candidatus Magnetoglobus multicellularis

Think back to when you learned about bacteria in school. How did your teacher describe them? Maybe they said that bacteria are invisible to the naked eye, are the causes of many diseases, or lack a nucleus. One descriptor your teacher almost certainly used was single-celled. Unlike a human, where trillions of cells work together to make a single living creature, bacteria are single-celled creatures – they have everything they need to live an independent life in one cell. We generally accept this as part of the definition of bacteria, but there is an exception.

Biologists define bacteria (shown here toward the bottom of this somewhat out-of-date tree of life) as strictly single-celled organisms.

As early as the 1980s, microbiologists knew of a group of bacterial species that are also multicellular organisms. These species have gone by many names over the years – magnetotactic multicellular aggregates, many-celled magnetotactic prokaryotes, and magnetotactic multicellular organisms. But they’re all defined by two traits – their multicellular structure and their ability to align with and move along the earth’s magnetic field. While the latter trait is fascinating, it’s known to exist in some other bacteria. Multicellularity, however, is not.

Researchers in Brazil (where these organisms were first discovered) named one of the species Candidatus Magnetoglobus multicellularis. It has become the most well-studied member of the multicellular bacteria, though no one has been able to grow it in a lab (giving it the status of Candidatus, since growth in a lab is required for a bacterium to become a named species). In nature, Ca. M. multicellularis takes the form of a sphere of cells with a hollow center. It’s similar to the shape of the blastula, one of the key stages in the development of embryos in humans and other animals.

The blastula, a hollow sphere of cells created early in the development of human and other animal embryos, is similar to the structure of Candidatus Magnetoglobus multicellularis.

Those familiar with microbiology might say that plenty of bacteria live in clusters of cells, and we don’t consider them multicellular. It’s true; colonies, biofilms, and other microbial superstructures all involve bacteria in close proximity, often working together for survival. However, these cells still behave and replicate individually. The cells in the sphere of Ca. M. multicellularis not only travel as a unit, but also are synchronized in their reproduction – cells physically grow in size, then one sphere splits into two identical spheres. We know of no instances where Ca. M. multicellularis exists as a single cell in nature. Researchers have been able to break up the spheres into single cells, but these cells never survived.

Candidatus Magnetoglobus multicellularis meets nearly all the defining characteristics of bacteria – we couldn’t realistically classify it as any other type of organism. Yet, it brazenly defies what we consider a core trait among all bacteria. Its multicellularity is just one example of the incredible ability of microorganisms to break the rules we set for them. In this way, studying microbiology constantly reminds us to question what we think we know.

Peer edited by Anneliese Long



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